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13 As we previously mentioned, drug-induced appetite suppression leads to nutrient deficiencies, which can cause brain fog, fatigue, mood shifts, and memory blips over time

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PIO, GLP-1R agonists, SGLT2 inhibitors and NAFLD: pathophysiological background PIO PIO, currently the only thiazolidinedione (TZD) in clinical practice, is a potent exogenous agonist of the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-) and to a lesser extent, PPAR- [17, 44]

As more non-weight indications emerge, including potential applications for addiction, Alzheimer disease, fatty liver disease, and chronic kidney disease, the relevance of BMI as the primary gatekeeper will diminish